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Herein, we report a senolytic strategy enabled by senescent cell-sensitive bioorthogonal tetrazine ligation. Our design is engineering a galactose (Gal) moiety into dihydrotetrazine, which serves both as recognition moiety for senescence-associated β-galactosidase (SA-β-gal) and a caging group for control of tetrazine activity.

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Herein, we report a senolytic strategy enabled by senescent cell-sensitive bioorthogonal tetrazine ligation. Our design is engineering a galactose (Gal) moiety into dihydrotetrazine, which serves both as recognition moiety for senescence-associated β-galactosidase (SA-β-gal) and a caging group for control of tetrazine activity.Connect NEC 2035 is a comprehensive plan to transform the Northeast Corridor, the busiest and most important rail corridor in the US. It outlines the projects, policies, and partnerships needed to improve mobility, reliability, and resilience for millions of travelers and businesses. You can read the entire 274 page overview of Connect NEC 2035 here. 10 The Student Guide to Using Connect McGraw-Hill Insight™ Connect Insight™ reports allow you to quickly assess your progress within a course, with visual data providing at-a-glance information about how you are performing. You can easily switch between Connect courses to view your results59 The three Special Reports are : Global Warming of 1.5°C (2018): an IPCC Special Report on the impacts of global warming of 1.5°C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicateThis report is part of the EU funded CONNECT project and considers the roles and responsibilities of actors, and the ways in which they work together, to respond to the …Division of Water. The City of Cleveland Division of Water (Cleveland Water) provides drinking water service to 1.4 million residential, commercial, and industrial customers in 80 communities across six counties in Greater Cleveland.The Warren Commission report is also available as a single PDF file (77.5MB) from the GPO website. It is keyword searchable. Title Page, Commission Members, Transmittal Letter. Foreword. Chapter 1: Summary and Conclusions. Chapter 2: The Assassination. Chapter 3: The Shots from the Texas School Book Depository.

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The notion of STEAM (Science, Technology, Engineering, Arts, and Mathematics) is an emerging discipline unique in its desire to provide a well-rounded approach to education. The chapters of this volume examine STEAM in a variety of settings, from kindergarten to higher education. Readers will learn about the practical considerations involved ...Annual and Sustainability Report was published February 29 2016. Annual and Sustainability Report 2015 (ENG) (PDF, 8 MB) Annual and Sustainability Report 2015 (SWE) (PDF, 7 MB) GRI G4 Supplement to the Annual and Sustainability Report 2015 (ENG) (PDF, 308 KB) Financial Event. March 25, 2015 / AB Volvo, Sweden.Clinician of the Future 2023: Education Edition has arrived. Elsevier Health’s landmark Clinician of the Future 2023: Education Edition report highlights new opportunities technology will play in supporting education and beyond. Explore the future.MSP Technology - IT Management Software - ConnectWiseNIS Investments Report 2023. Download. PDF document, 6.31 MB. This report aims at providing policy makers with evidence to assess the effectiveness of the …5 days ago · We report on an analytical and biological validation of a commercial cortisol enzyme immunoassay (EIA) to measure glucocorticoids (GC) in feces of Geoffroy's spider monkeys (Ateles geoffroyi). Validation of endocrinological methods for each sample matrix and study species is crucial to establish that the methods produce reliable results. The Volkswagen app is the digital companion for your Volkswagen. It allows you to use mobile online services, irrespective of which model you drive with which drive type and whether you have a VW Connect, We Connect or Car-Net contract. With the Volkswagen app, for instance, as the primary user, you can view your Volkswagen vehicle’s current ...Connect NEC 2035 is a comprehensive plan to transform the Northeast Corridor, the busiest and most important rail corridor in the US. It outlines the projects, policies, and partnerships needed to improve mobility, reliability, and resilience for millions of travelers and businesses. You can read the entire 274 page overview of Connect NEC 2035 here. Connect allowed me to make class time more meaningful for students. Rather than lecture on concepts or attempt to discuss concepts from the reading in a room of students who had not read, Connect allowed me to more effectively use class time on activities that strengthen student learning.” – Dr. Erin Lynch-Alexander, professor of Education, Mar 15, 2021 · SWE’s assessment of the most significant social science research from 2020 offers insights and analysis, plus recommendations for future study and interventions that might, finally, lead to greater gender equity in STEM. The underrepresentation of women in engineering and other technical fields remains the subject of extensive research. Engineers, social scientists, and educators continue to ...

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State of Cybersecurity Report. 1 in 5 cybersecurity professionals and leaders refuse to bet a chocolate bar that they could prevent a damaging security breach in 2023 – but why? Ivanti Solutions Summit 2024 April 9–12 / Grapevine, TX / Gaylord Texan Resort & Convention Center ... Connect with peers and industry leaders, discover tools you ...

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